| Cationic liposome coupled endostatin gene for treatment of peritoneal colon cancer. | |
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MedLine Citation:
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PMID: 20373131 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Therapy targeting cancer blood vessels requires unwavering pharmacokinetics of antiangiogenic therapeutics to neutralize the excess pro-angiogenic factors constantly secreted by tumor cells. Gene therapies have been explored to effectively create a microenvironment less favorable for angiogenesis and tumor expansion. In this study, we examined the inhibitory effect of cationic liposome coupled with the murine endostatin gene (Lipo/mEndo) on growth of intraperitoneal disseminated colon cancer models. Intraperitoneal injection of Lipo/mEndo inhibited bioluminescent signals emitted from CT26 colon cancer cells stably expressing luciferase in the living mice and prolonged their survival times. Endostatin gene therapy suppressed the colony forming capability and VEGF concentration of ascites obtained from treated mice by 74 and 60%, respectively. When tested in a similar model using HCT116 human colon cancer cells, Lipo/mEndo and bevacizumab displayed comparable repressive effects on ascites formation and tumor foci dissemination on mesentery of experimental mice. Our results implicate that cationic liposome coupled endostatin gene therapy may be a clinically effective treatment for intraperitoneal disseminated colon cancer. |
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Authors:
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Keng-Li Lan; Fu Ou-Yang; Sang-Hue Yen; How-Ling Shih; Keng-Hsin Lan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-07 |
Journal Detail:
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Title: Clinical & experimental metastasis Volume: 27 ISSN: 1573-7276 ISO Abbreviation: Clin. Exp. Metastasis Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-06-24 Revised Date: 2010-07-08 |
Medline Journal Info:
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Nlm Unique ID: 8409970 Medline TA: Clin Exp Metastasis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 307-18 Citation Subset: IM |
Affiliation:
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Cancer Center, Taipei Veterans General Hospital, 11217, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Base Sequence Cations* Cell Line, Tumor Colonic Neoplasms / metabolism, pathology, therapy* DNA Primers Endostatins / genetics, therapeutic use* Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Gene Therapy* Humans Liposomes* Mice Peritoneal Neoplasms / metabolism, pathology, secondary, therapy* Reverse Transcriptase Polymerase Chain Reaction Vascular Endothelial Growth Factor A / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cations; 0/DNA Primers; 0/Endostatins; 0/Liposomes; 0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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