Document Detail


Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle.
MedLine Citation:
PMID:  23303468     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polymeric micelle prepared through the self-assembly of cationic cholesterol-modified gelatin was tested for siRNA delivery. It exerted the desired effect of gene knockdown in HeLa cells stably expressing the luciferase gene and achieved a two-fold increase in the knockdown ability when compared to Lipofectamine® 2000. It was found that the polymeric micelle exhibited excellent stability and increased the biological stability of the siRNA in serum.
Authors:
Pallavi Ananda Kadengodlu; Toshiro Aigaki; Hiroshi Abe; Yoshihiro Ito
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Molecular bioSystems     Volume:  -     ISSN:  1742-2051     ISO Abbreviation:  Mol Biosyst     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wakoshi, Saitama 351-0198, Japan. y-ito@riken.jp h-abe@riken.jp.
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