| Cationic carriers of genetic material and cell death: a mitochondrial tale. | |
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MedLine Citation:
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PMID: 20381448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central to gene therapy technology has been the use of cationic polymers as vectors for DNA and RNA (polyfectins). These have been presumed to be safer than viral systems which, for example, have been found to switch on oncogenes. Two key polycations that have been intensively researched for use as synthetic vectors are poly(ethylenimine) and poly(L-lysine). A frequent stumbling block with these polyfectins is that long-term gene expression in cell lines has not been achieved. Recently it has transpired that both of these polycations can induce mitochondrially mediated apoptosis. It is the aim of this review to discuss the mechanisms behind the observed polycation toxicity including roles for little studied cellular organelles in the process such as the lysosome and endoplasmic reticulum. |
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Authors:
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A Christy Hunter; S Moein Moghimi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-08 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1797 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Jun-Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1203-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Cockcroft Building, Lewes Road, Brighton, East Sussex BN2 4GJ, UK. c.hunter@bton.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Cations / toxicity Cell Death / drug effects* Cell Line Drug Carriers / chemistry, toxicity Drug Delivery Systems Gene Therapy Genetic Vectors / chemistry*, toxicity* Humans Mitochondria / drug effects* Polyamines / toxicity Polyethyleneimine / toxicity Polylysine / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Cations; 0/Drug Carriers; 0/Polyamines; 0/polycations; 25104-18-1/Polylysine; 9002-98-6/Polyethyleneimine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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