Document Detail


A Cationic Phospholipid-Detergent Conjugate as a New Efficient Carrier for siRNA Delivery.
MedLine Citation:
PMID:  22362588     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A "grapnel" lipid: Conjugation of Triton X-100 with DOPC provides a new class of nucleic acid carrier. The lamellar phase forming cationic conjugate has no hemolytic activity and efficiently delivers siRNA into the cytosol of mammalian cells. Covalent anchoring of the detergent to the phospholipid and the dangling hydrophobic part of the detergent moiety appear to be essential for siRNA delivery and efficient gene silencing.
Authors:
Philippe Pierrat; Gaëlle Creusat; Gilles Laverny; Françoise Pons; Guy Zuber; Luc Lebeau
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-23
Journal Detail:
Title:  Chemistry (Weinheim an der Bergstrasse, Germany)     Volume:  -     ISSN:  1521-3765     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513783     Medline TA:  Chemistry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Laboratoire de Conception et Application de Molécules Bioactives, CNRS, Université de Strasbourg, Faculté de Pharmacie, 74 Route du Rhin, BP 60024, Illkirch (France), Fax: (+33) 333-6885-4306.
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