| Cation-induced aggregation of acidic phospholipid vesicles: the role of fatty acid unsaturation and cholesterol. | |
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MedLine Citation:
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PMID: 2060064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cation-induced aggregation of acidic phospholipid vesicles consisting of dimyristoylphosphatidylglycerol (DMPG), dipalmitoylphosphatidylserine (DPPS), phosphatidylserine from bovine brain (brPS), and phosphatidylglycerol from egg yolk (eggPG) was studied. Significant differences were evident in the NaCl-induced aggregation of fully saturated and unsaturated acidic phospholipid vesicles. The threshold NaCl concentration of vesicle aggregation ([NaCl]Thr) for DPPS vesicles was 320 mM compared to 610 mM observed for brPS vesicles. For DMPG vesicles the [NaCl]Thr was 430 mM and no aggregation of eggPG vesicles could be observed upon addition of NaCl. The threshold CaCl2 concentrations of aggregation of DMPG and eggPG vesicles were 2.3 and 4.9 mM, respectively. The corresponding threshold CaCl2 concentrations for DPPS and brPS vesicles were 0.85 mM and 1.3 mM, respectively. The inclusion of cholesterol into vesicles attenuated NaCl- and CaCl2-induced aggregation of DMPG and DPPS vesicles. However, enhancement of aggregation by inclusion of cholesterol was observed in the case of NaCl-induced aggregation of brPS vesicles. It is concluded that cation mediated membrane-membrane interactions depend, in addition to polar headgroup structure, on the fatty acid composition of the phospholipids also. |
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Authors:
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K K Eklund; J E Takkunen; P K Kinnunen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 57 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 1991 Jan-Feb |
Date Detail:
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Created Date: 1991-08-02 Completed Date: 1991-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 59-66 Citation Subset: IM |
Affiliation:
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Department of Medical Chemistry, University of Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Chemistry Calcium / pharmacology* Cholesterol / chemistry* Fatty Acids, Unsaturated / chemistry* Hydrogen-Ion Concentration Liposomes* Membranes, Artificial Phosphatidylglycerols / chemistry Phosphatidylserines / chemistry Phospholipids / chemistry* Sodium / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated; 0/Liposomes; 0/Membranes, Artificial; 0/Phosphatidylglycerols; 0/Phosphatidylserines; 0/Phospholipids; 3036-82-6/dipalmitoylphosphatidylserine; 57-88-5/Cholesterol; 61361-72-6/dimyristoylphosphatidylglycerol; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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