Document Detail


Cathodal stimulation of human MT+ leads to elevated fMRI signal: a tDCS-fMRI study.
MedLine Citation:
PMID:  22475855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Transcranial direct current stimulation (tDCS) was reintroduced about a decade ago as a tool for inducing long-lasting changes in cortical excitability. Recently it has been shown that both motor and cognitive functions can be influenced by tDCS. Here, we tested the effect of tDCS on the blood-oxygen level dependent (BOLD) signal evoked by coherent visual motion using functional magnetic resonance imaging (fMRI).
METHODS: The subjects underwent 10 min of cathodal and sham tDCS, applied over the right MT+. Following stimulation, random dot kinomatograms (RDK) with different percentages (10%, 30%, 50%) of coherently moving dots were presented.
RESULTS: All motion stimuli activated MT+ in both stimulation conditions. However, cathodal stimulation led to an increase in fMRI signal in MT+ when compared to sham stimulation. This effect did not depend on the coherence level of the visual stimulus.
CONCLUSIONS: Here, we show for the first time, that cathodal tDCS stimulation leads to elevated fMRI signal in the human visual cortex.
Authors:
Andrea Antal; Gyula Kovács; Leila Chaieb; Csaba Cziraki; Walter Paulus; Mark W Greenlee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Restorative neurology and neuroscience     Volume:  30     ISSN:  1878-3627     ISO Abbreviation:  Restor. Neurol. Neurosci.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-28     Completed Date:  2013-03-26     Revised Date:  2013-04-10    
Medline Journal Info:
Nlm Unique ID:  9005499     Medline TA:  Restor Neurol Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  255-63     Citation Subset:  IM    
Affiliation:
Department of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Göttingen, Germany. Aantal@gwdg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebrovascular Circulation / physiology*
Electric Stimulation / instrumentation,  methods*
Electrodes / utilization
Female
Humans
Magnetic Resonance Imaging / methods
Male
Motion Perception / physiology*
Temporal Lobe / physiology*
Visual Cortex / physiology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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