Document Detail

Catheter patency and function after catheter sheath disruption: a pilot study.
MedLine Citation:
PMID:  17942775     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Hemodialysis catheters are frequently complicated by dysfunction from fibrin sheaths. Previous studies of sheath disruption have methodologic limitations but suggest that the patency after disruption is short. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A randomized, controlled, pilot trial was conducted to investigate the impact of angioplasty sheath disruption on catheter patency and function. Forty-seven long-term hemodialysis patients with secondary, refractory catheter dysfunction underwent guidewire exchange to replace their catheters. RESULTS: Sheaths were present in 33 (70%) of the 47 patients. In 18 patients who were randomly assigned to disruption, the median time to repeat dysfunction was 373 d compared with 97.5 d in patients who did not undergo disruption (P = 0.22), and the median time to repeat catheter exchange was 411 and 198 d, respectively (P = 0.17). Mean blood flow (340 versus 329 ml/min; P < 0.001) and urea reduction ratio (72 versus 66%; P < 0.001) were higher in the disruption group. Fourteen patients had no sheaths, and their median times to repeat dysfunction and repeat exchange were 849 and 879 d, respectively. Patients with no sheaths had higher urea reduction ratio (73 versus 66%; P < 0.001) and a lower percentage of inadequate hemodialysis treatments (9.8 versus 27%; P = 0.01) and treatments that required thrombolytics (1.8 versus 5.0%; P = 0.03) than patients with sheaths that were not disrupted. CONCLUSIONS: Disrupting sheaths by angioplasty balloon results in durable catheter patency and modestly improves blood flow and clearance over the duration of catheter use.
Matthew J Oliver; David C Mendelssohn; Robert R Quinn; Elizabeth P Richardson; Deeraj K Rajan; Robyn A Pugash; Joyce A Hiller; Alex J Kiss; Charmaine E Lok
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-10-17
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  2     ISSN:  1555-905X     ISO Abbreviation:  -     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1201-6     Citation Subset:  IM    
Sunnybrook Health Sciences Centre, Room A239, 2075 Bayview Avenue, Toronto, Canada M4N 3M5.
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MeSH Terms
Angioplasty, Balloon / methods*
Catheterization, Central Venous / instrumentation*
Catheters, Indwelling*
Graft Occlusion, Vascular / therapy*
Pilot Projects
Renal Dialysis / adverse effects*,  instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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