Document Detail

Catheter lock solutions to prevent bloodstream infections in high-risk hemodialysis patients.
MedLine Citation:
PMID:  17215571     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Antimicrobial catheter lock solutions (CLS) have been shown to prevent bacteremia in chronic hemodialysis (HD) patients with new HD catheters. However, there is little information regarding the usage of these solutions in patients who have a history of recurrent bacteremia and are at very high risk of infection. The purpose of this investigation was to identify the efficacy of these solutions in such high-risk patients. METHODS: A retrospective chart review was performed to identify patients who had a history of recurrent bacteremia and had received prophylaxis with antimicrobial CLS. RESULTS: Nine patients with recurrent bacteremia were identified. These patients had received prophylaxis with minocycline/EDTA, gentamicin/heparin, or vancomycin/heparin solutions. The catheter-related bacteremia rate was 9.13 per 1,000 catheter days prior to the use of CLS, 1.04 during use of solution, and 7.94 after the CLS were discontinued (p < 0.001). CONCLUSIONS: These results show a dramatic effect of antimicrobial CLS on the prevention of catheter-related bacteremia.
Theodore Feely; Angela Copley; Anthony J Bleyer
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-01-11
Journal Detail:
Title:  American journal of nephrology     Volume:  27     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-07     Completed Date:  2007-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Section on Nephrology, Wake Forest University School of Medicine and Health Systems Management, Winston-Salem, NC 27157, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Bacteremia / epidemiology,  etiology,  prevention & control*
Catheters, Indwelling / adverse effects*,  microbiology
Dialysis Solutions / therapeutic use*
Drug Combinations
Equipment Failure
Follow-Up Studies
Middle Aged
Renal Dialysis / adverse effects,  methods*
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Dialysis Solutions; 0/Drug Combinations

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