| Catheter lock solutions to prevent bloodstream infections in high-risk hemodialysis patients. | |
MedLine Citation:
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PMID: 17215571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Antimicrobial catheter lock solutions (CLS) have been shown to prevent bacteremia in chronic hemodialysis (HD) patients with new HD catheters. However, there is little information regarding the usage of these solutions in patients who have a history of recurrent bacteremia and are at very high risk of infection. The purpose of this investigation was to identify the efficacy of these solutions in such high-risk patients. METHODS: A retrospective chart review was performed to identify patients who had a history of recurrent bacteremia and had received prophylaxis with antimicrobial CLS. RESULTS: Nine patients with recurrent bacteremia were identified. These patients had received prophylaxis with minocycline/EDTA, gentamicin/heparin, or vancomycin/heparin solutions. The catheter-related bacteremia rate was 9.13 per 1,000 catheter days prior to the use of CLS, 1.04 during use of solution, and 7.94 after the CLS were discontinued (p < 0.001). CONCLUSIONS: These results show a dramatic effect of antimicrobial CLS on the prevention of catheter-related bacteremia. |
Authors:
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Theodore Feely; Angela Copley; Anthony J Bleyer |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-01-11 |
Journal Detail:
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Title: American journal of nephrology Volume: 27 ISSN: 1421-9670 ISO Abbreviation: Am. J. Nephrol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-03-07 Completed Date: 2007-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 24-9 Citation Subset: IM |
Copyright Information:
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2007 S. Karger AG, Basel |
Affiliation:
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Section on Nephrology, Wake Forest University School of Medicine and Health Systems Management, Winston-Salem, NC 27157, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Bacterial Agents / therapeutic use* Bacteremia / epidemiology, etiology, prevention & control* Catheters, Indwelling / adverse effects*, microbiology Dialysis Solutions / therapeutic use* Drug Combinations Equipment Failure Female Follow-Up Studies Humans Incidence Male Middle Aged Renal Dialysis / adverse effects, methods* Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Dialysis Solutions; 0/Drug Combinations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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