| Catheter-directed thrombolysis with the Endowave system in the treatment of acute massive pulmonary embolism: a retrospective multicenter case series. | |
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MedLine Citation:
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PMID: 18295696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy of thrombolysis with the EndoWave peripheral infusion system in the treatment of patients with massive pulmonary embolism (PE) as compared to patients treated with catheter-directed thrombolysis. MATERIALS AND METHODS: Ten patients (five men and five women; age range, 31-85 years; mean age, 54.20 years) with massive acute PE (17 lesions) were treated with ultrasonography (US)-assisted catheter-directed thrombolysis with the Endowave system. All patients had hypoxia and dyspnea. No patient had contraindication for thrombolysis. Angiographic findings, duration of lysis, dose of thrombolytics used, and procedural complications were recorded. Thrombolytics used were urokinase, tissue-type plasminogen activator (tPA), and Reteplase. RESULTS: Complete thrombus removal was achieved in 13 of the 17 lesions (76%), near complete thrombolysis was achieved in three lesions (18%), and partial thrombolysis was achieved in one lesion (6%). The mean time of thrombolysis was 24.76 hours +/- 8.44 (median, 24 hours). The mean dose of tPA used for the Endowave group was 0.88 mg/h +/- 0.19 (13 lesions). CONCLUSIONS: US-assisted catheter-directed thrombolysis is an effective method for treating massive thrombolysis. It has the potential to shorten the time of lysis and lower the dose of thrombolytics. |
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Authors:
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Abbas Chamsuddin; Lama Nazzal; Brandon Kang; Irwin Best; Gail Peters; Sepehr Panah; Louis Martin; Curtis Lewis; Chadi Zeinati; John W Ho; Anthony C Venbrux |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 19 ISSN: 1051-0443 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-25 Completed Date: 2008-07-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 372-6 Citation Subset: IM |
Affiliation:
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Department of Vascular and Interventional Radiology, Emory University Hospital, Atlanta, GA 30345, USA. abbas_chamsuddin@emoryhealthcare.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Catheterization Female Fibrinolytic Agents / administration & dosage Humans Male Middle Aged Pulmonary Embolism / drug therapy*, ultrasonography Recombinant Proteins / administration & dosage Retrospective Studies Thrombolytic Therapy / instrumentation, methods* Tissue Plasminogen Activator / administration & dosage Urokinase-Type Plasminogen Activator / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Recombinant Proteins; 133652-38-7/reteplase; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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