| Catheter-based renal denervation for treatment of resistant hypertension. | |
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MedLine Citation:
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PMID: 22677237 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Activation of renal sympathetic nerves is associated with the development of hypertension. Catheter-based renal sympathetic denervation with radiofrequency energy ablation is a new promising treatment option for resistant hypertension. We here report the first Danish experiences and results with this technique. MATERIAL AND METHODS: Nine patients with resistant hypertension and a day-time 24-hour ambulatory blood pressure (BP) of 152/89 mmHg ± 10/10 (standard deviation) mmHg despite treatment with 5.4 ± 1.4 anti-hypertensive drugs underwent catheter-based renal sympathetic denervation with the Symplicity catheter. RESULTS: No periprocedural complications or adverse events during follow-up were observed. Seven patients received complete ablation and two patients only partial ablation. Five patients responded to the treatment with a reduction in day-time 24-hour ambulatory BP from 158/94 ± 13/9 mmHg to 139/82 ± 10/8 mmHg (p < 0.05) at the one month follow-up and a reduction in the number of anti-hypertensive drugs from 5.4 ± 1.6 to 3.4 ± 0.9 (p < 0.05). BP in the remaining four patients was not significantly changed and antihypertensive therapy was not changed. CONCLUSION: Catheter-based renal sympathetic denervation is a feasible and in several cases also effective treatment option for patients with resistant hypertension. Adequately designed controlled trials are needed to assess the long-term safety and the full potential of this treatment. FUNDING: not relevant. TRIAL REGISTRATION: not relevant. |
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Authors:
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Henrik Vase; Ole Norling Mathiassen; Anne Kaltoft; Erling Bjerregaard Pedersen; Kent Lodberg Christensen; Niels Henrik Buus; Ole Lederballe; Jens Flensted Lassen; Hans Erik Bøtker; Leif Thuesen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Danish medical journal Volume: 59 ISSN: 2245-1919 ISO Abbreviation: Dan Med J Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101576205 Medline TA: Dan Med J Country: Denmark |
Other Details:
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Languages: eng Pagination: A4439 Citation Subset: IM |
Affiliation:
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Hjertemedicinsk Afdeling, Aarhus Universitetshospital, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark. henrikvase@dadlnet.dk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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