Document Detail


Cathepsin proteases in Toxoplasma gondii.
MedLine Citation:
PMID:  21660658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cysteine proteases are important for the growth and survival of apicomplexan parasites that infect humans. The apicomplexan Toxoplasma gondii expresses five members of the C1 family of cysteine proteases, including one cathepsin L-like (TgCPL), one cathepsin B-like (TgCPB) and three cathepsin C-like (TgCPC1, 2 and 3) proteases. Recent genetic, biochemical and structural studies reveal that cathepsins function in microneme and rhoptry protein maturation, host cell invasion, replication and nutrient acquisition. here, we review the key features and roles of T. gondii cathepsins and discuss the therapeutic potential for specific inhibitor development.
Authors:
Zhicheng Dou; Vern B Carruthers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  712     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-10     Completed Date:  2011-09-30     Revised Date:  2014-04-20    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Cathepsins / chemistry,  genetics,  metabolism*,  therapeutic use
Humans
Molecular Sequence Data
Phylogeny
Protein Transport
Toxoplasma / enzymology*
Grant Support
ID/Acronym/Agency:
R01 AI063263/AI/NIAID NIH HHS; R01AI063263/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.-/Cathepsins
Comments/Corrections

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