| Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90. | |
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MedLine Citation:
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PMID: 16364318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing evidence suggests that lysosomal cysteine proteases cathepsins contribute to the progression of cell apoptosis. Here we found that apoptosis of ovarian cancer cells OV-90 triggered by TNF was cathepsin B-depended. Two cathepsin B binding proteins, bikunin and TSRC1, were identified by yeast two-hybrid method and the interactions were confirmed in vitro and in vivo. Overexpression of bikunin could suppress TNF-induced apoptosis of OV-90 cells, and TSRC1 overexpression had an opposite effect on apoptosis. The presented results suggest that cathepsin B and its interacting proteins, bikunin and TSRC1, are involved in the apoptotic pathway of ovarian cancer cells. |
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Authors:
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Jianping Liu; Qian Guo; Buxin Chen; Yao Yu; Hong Lu; Yu-Yang Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-12 |
Journal Detail:
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Title: FEBS letters Volume: 580 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-02 Completed Date: 2006-02-14 Revised Date: 2007-05-23 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 245-50 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects* Autocrine Communication / genetics Cathepsin B / genetics, metabolism* Cell Line, Tumor Female Gene Expression Humans Membrane Glycoproteins / genetics, metabolism* Ovarian Neoplasms / metabolism* Thrombospondins / genetics, metabolism* Trypsin Inhibitor, Kunitz Soybean / genetics, metabolism* Tumor Necrosis Factor-alpha / metabolism, pharmacology* Two-Hybrid System Techniques |
| Chemical | |
Reg. No./Substance:
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0/ADAMTSL4 protein, human; 0/Membrane Glycoproteins; 0/SPINT2 protein, human; 0/Thrombospondins; 0/Tumor Necrosis Factor-alpha; 9088-41-9/Trypsin Inhibitor, Kunitz Soybean; EC 3.4.22.1/Cathepsin B |
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