Document Detail


Cathepsin B in predicting the extent of the cervix carcinoma.
MedLine Citation:
PMID:  7617069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The value of cathepsin B activity in determining the extent of disease was investigated in 106 patients with carcinoma of the cervix uteri and in 20 women with dysplasia of the cervix uteri. The measurements of serum and tumor cathepsin B activity were performed before treatment. The levels of cathepsin B were estimated by direct fluorimetric assay based on the use of 2-Phe-Arg-NMec as a substrate. The results show that the mean serum and tumor activity of this enzyme increase with progression of neoplastic disease and was closely dependent on clinical stage of cervical carcinoma. Also, we found higher serum and tumor levels of cathepsin B activities in patients with clinical early disease (FIGO Stage Ib and IIa) in whom metastases to pelvic lymph nodes were detected than in patients with disease limited to the cervix uteri (p < 0.001, t-test). Enhanced activity of cathepsin B was observed in 64% of patients with cervical carcinoma.
Authors:
R Makarewicz; G Drewa; W Szymanski; I Skonieczna-Makarewicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  42     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Affiliation:
Department of Brachytherapy, Regional Cancer Center, Bydgoszcz, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analysis of Variance
Carcinoma / enzymology*
Case-Control Studies
Cathepsin B / blood,  metabolism*
Female
Humans
Least-Squares Analysis
Linear Models
Middle Aged
Predictive Value of Tests
Uterine Cervical Dysplasia / enzymology*
Uterine Cervical Neoplasms / enzymology*
Chemical
Reg. No./Substance:
EC 3.4.22.1/Cathepsin B

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