Document Detail

Cathepsin B in predicting the extent of the cervix carcinoma.
MedLine Citation:
PMID:  7617069     Owner:  NLM     Status:  MEDLINE    
The value of cathepsin B activity in determining the extent of disease was investigated in 106 patients with carcinoma of the cervix uteri and in 20 women with dysplasia of the cervix uteri. The measurements of serum and tumor cathepsin B activity were performed before treatment. The levels of cathepsin B were estimated by direct fluorimetric assay based on the use of 2-Phe-Arg-NMec as a substrate. The results show that the mean serum and tumor activity of this enzyme increase with progression of neoplastic disease and was closely dependent on clinical stage of cervical carcinoma. Also, we found higher serum and tumor levels of cathepsin B activities in patients with clinical early disease (FIGO Stage Ib and IIa) in whom metastases to pelvic lymph nodes were detected than in patients with disease limited to the cervix uteri (p < 0.001, t-test). Enhanced activity of cathepsin B was observed in 64% of patients with cervical carcinoma.
R Makarewicz; G Drewa; W Szymanski; I Skonieczna-Makarewicz
Related Documents :
2404249 - Hürthle-cell neoplasms of the thyroid gland.
18222769 - An approach to automated detection of tumors in mammograms.
18166319 - Mage-a and ny-eso-1 expression in cervical cancer: prognostic factors and effects of ch...
21731279 - Bilateral maxillary brown tumors in a patient with primary hyperparathyroidism: report ...
9258069 - The impact of tumor size on clinical outcome in patients with localized renal cell carc...
25455269 - Fanconi anemia and the development of leukemia.
10983749 - Somatostatin receptor scintigraphy: the definitive technique for characterizing vasoact...
3098409 - Increase in po2 and radiosensitivity of tumors by fluosol-da (20%) and carbogen.
20149869 - Tumor targeting of functionalized lipid nanoparticles: assessment by in vivo fluorescen...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  42     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Department of Brachytherapy, Regional Cancer Center, Bydgoszcz, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Carcinoma / enzymology*
Case-Control Studies
Cathepsin B / blood,  metabolism*
Least-Squares Analysis
Linear Models
Middle Aged
Predictive Value of Tests
Uterine Cervical Dysplasia / enzymology*
Uterine Cervical Neoplasms / enzymology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Changes of natural killer cytotoxic activity and natural killer sensitivity during growth of Bomirsk...
Next Document:  Combined radioprotective effect of Broncho-Vaxom and WR-2721 on hemopoiesis and circulating blood ce...