| Cathepsin B as a cancer target. | |
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MedLine Citation:
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PMID: 23293836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers. Cathepsin B is normally associated with the lysosomes involved in autophagy and immune response, but its aberrant expression has been shown to lead to cancers. Areas covered: This review highlights the oncogenic role of cathepsin B, discusses the regulation of cathepsin B in light of oncogenesis, discusses the role of cathepsin B as a signaling molecule, and highlights the therapeutic potential of targeting cathepsin B. Expert opinion: Targeting cathepsin B alone does not appear to abolish tumor growth, and this is probably because cathepsin B appears to have diverse functions and influence numerous pathways. It is not clear whether global suppression of cathepsin B activity or expression would produce unintended effects or cause the activation or suppression of unwanted pathways. A localized approach for targeting the expression of cathepsin B would be more relevant. Moreover, a combination of targeting cathepsin B with other relevant oncogenic molecules has significant therapeutic potential. |
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Authors:
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Christopher S Gondi; Jasti S Rao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-8 |
Journal Detail:
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Title: Expert opinion on therapeutic targets Volume: - ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Illinois College of Medicine at Peoria, Department of Cancer Biology and Pharmacology and Neurosurgery , Peoria, IL , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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