Document Detail

Cath6, a bHLH atonal family proneural gene, negatively regulates neuronal differentiation in the retina.
MedLine Citation:
PMID:  20730907     Owner:  NLM     Status:  MEDLINE    
Basic helix-loop-helix (bHLH) transcription factors play important roles in cell type specification and differentiation during the development of the nervous system. In this study, we identified a chicken homolog of Atonal 8/ath6 (Cath6) and examined its role in the developing retina. Unlike other Atonal-family proneural genes that induce neuronal differentiation, Cath6 was expressed in stem cell-like progenitor cells in the marginal region of the retina, and its overexpression inhibited neuronal differentiation. A Cath6 fused with a VP16 transactivation domain recapitulated the inhibitory effect of Cath6 on neuronal differentiation, indicating that Cath6 functions as a transcription activator. These results demonstrate that Cath6 constitutes a unique member of the Atonal-family of genes in that it acts as a negative regulator of neuronal differentiation.
Fumi Kubo; Shinichi Nakagawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2492-500     Citation Subset:  IM    
Copyright Information:
Developmental Dynamics 239:2492-2500, 2010. © 2010 Wiley-Liss, Inc.
RIKEN Advanced Science Institute, Wako, Saitama, Japan.
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MeSH Terms
Basic Helix-Loop-Helix Transcription Factors / classification,  genetics*,  metabolism*
Cell Differentiation / physiology*
Chick Embryo
Gene Expression Regulation, Developmental
Neurons / cytology,  physiology*
Retina / cytology*,  metabolism,  physiology*
Retinal Ganglion Cells / cytology,  physiology
Stem Cells / cytology,  metabolism
Transcription, Genetic
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors

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