| Categorization in the monkey hippocampus: a possible mechanism for encoding information into memory. | |
| | |
MedLine Citation:
|
PMID: 14978264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mammalian hippocampus processes sensory information into memory. The neurobiological basis of this representation, as well as the type of information that is encoded, is central to understanding how memories are formed. Normally, there is an infinite amount of information that could be encoded for any given stimulus. Thus, the question arises as to how the hippocampus selects and encodes features of a given stimulus. Here, we show that neurons in the hippocampus of the monkey appear to categorize types of visual stimuli presented in a delayed-match-to-sample memory task. By extracting unique combinations of features, these category cells are able to encode aspects of behaviorally important images instead of encoding all visual details. The subject is then able to rapidly select an appropriate response to that stimulus when distracting stimuli are presented simultaneously, thereby facilitating performance. Moreover, across animals, this specific type of encoding differed considerably. Just as in humans, different monkeys attended to and selected different aspects of the same stimulus image, most likely reflecting different histories, strategies, and expectations residing within individual hippocampal networks. |
| | |
Authors:
|
Robert E Hampson; Tim P Pons; Terrence R Stanford; Sam A Deadwyler |
Related Documents
:
|
20156544 - Treadmill exercise prevents aging-induced failure of memory through an increase in neur... 10495024 - Complimentary roles for hippocampal versus subicular/entorhinal place cells in coding p... 18955704 - A double dissociation revealing bidirectional competition between striatum and hippocam... 10074814 - Neuropsychological effects of vasopressin in healthy humans. 18762064 - The speech naturalness of people who stutter speaking under delayed auditory feedback a... 20673914 - The development of children's early memory skills. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2004-02-20 |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 101 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2004 Mar |
Date Detail:
|
Created Date: 2004-03-03 Completed Date: 2004-06-17 Revised Date: 2013-04-18 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
|
Languages: eng Pagination: 3184-9 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain Mapping / methods Electric Stimulation Hand Hippocampus / cytology*, physiology* Humans Learning / physiology* Macaca mulatta Memory / physiology* Motor Activity Pattern Recognition, Visual / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
DA00119/DA/NIDA NIH HHS; DA06634/DA/NIDA NIH HHS; MH61397/MH/NIMH NIH HHS; NS048106/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis.
Next Document: Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.