Document Detail


Categorization of cysts and steroid levels in breast cyst fluid.
MedLine Citation:
PMID:  1551138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several reports indicate that patients with macrocysts have a two- to fourfold higher risk of developing cancer. The fluid filling the cysts (breast cyst fluid, BCF) contains unusual amounts of biologically active substances, including hormones and metabolites. The accumulation of steroid conjugates, such as androgen and estrogen sulfates, deserves interest. Measuring BCF cations (K+, Na+) permits classification of cysts into two major subsets (type I and type II), conceivably associated with a different degree and with a turnover of apocrine cells in the lining epithelium. Type I (high K+/Na+ ratio) and type II (low K+/Na+ ratio) cysts display different patterns of steroid analytes and steroid-binding proteins. There are many gaps in our understanding of the relationship between local steroids and hypersecretion of fluid in the terminal duct lobular units with eventual appearance of cysts. Accumulating biochemical and epidemiological data, however, point to recurrent, multiple type I cysts as a marker of endocrine risk, i.e., of a whole-organ promoting status toward proliferative premalignant lesions.
Authors:
A Angeli; P Caraci; B Puligheddu; M Torta; F Orlandi; L Dogliotti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer detection and prevention     Volume:  16     ISSN:  0361-090X     ISO Abbreviation:  Cancer Detect. Prev.     Publication Date:  1992  
Date Detail:
Created Date:  1992-04-29     Completed Date:  1992-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704778     Medline TA:  Cancer Detect Prev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-6     Citation Subset:  IM    
Affiliation:
Department of Clinical and Biological Sciences, University of Torino, Italy.
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MeSH Terms
Descriptor/Qualifier:
Breast Neoplasms / etiology
Electrolytes / analysis
Exudates and Transudates / metabolism*
Female
Fibrocystic Breast Disease / metabolism*
Humans
Risk Factors
Steroids / metabolism*
Chemical
Reg. No./Substance:
0/Electrolytes; 0/Steroids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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