Document Detail

Catecholamines and vitiligo.
MedLine Citation:
PMID:  1321419     Owner:  NLM     Status:  MEDLINE    
The levels of some catecholamine metabolites, namely homovanillic acid (HVA), vanilmandelic acid (VMA), 3-methoxytyramine (MT), normetanephrine (NMN), metanephrine (MN), 3,4-dihydroxy mandelic acid (DOMAC), and 3,4-dihydroxy phenylacetic acid (DOPAC), have been evaluated in the 24 hr urines of 150 patients affected with different types of vitiligo and in 50 healthy age-matched individuals. The patients were divided into three groups according to the different phases of the disease. The first group included subjects affected either with the early active phase or with progressive increase in both number and/or the size of previous lesions. The second group included patients in whom no new lesions had appeared for between 4-8 months. In the third group the white areas had been stable for 1-5 years. The first and second groups showed values of HVA and VMA from 4 to 10 times and from 1/2 to 3 times higher respectively than those of controls, while no significant differences were found between the third group and controls. Our results clearly show that a significant increase of urinary levels of HVA and VMA, deriving respectively from dopamine and from norepinephrine and epinephrine characterizes the onset and the progressive active phases of vitiligo, irrespective of the type of distribution. The increased release of catecholamines from the autonomic nerve endings in the microenvironment of melanocytes in the affected skin areas might be involved in the etiopathogenesis of vitiligo through two main mechanisms: (1) a direct cytotoxic action of catecholamines and/or their o-diphenol catabolites; (2) an indirect action.(ABSTRACT TRUNCATED AT 250 WORDS)
A Morrone; M Picardo; C de Luca; O Terminali; S Passi; F Ippolito
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  5     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-08-19     Completed Date:  1992-08-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  65-9     Citation Subset:  IM    
San Gallicano Dermatological Institute, Rome, Italy.
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MeSH Terms
Catecholamines / physiology,  urine*
Free Radicals
Middle Aged
Receptors, Adrenergic, alpha / physiology
Stress, Physiological / complications,  physiopathology
Vitiligo / epidemiology,  etiology,  pathology,  urine*
Reg. No./Substance:
0/Catecholamines; 0/Free Radicals; 0/Receptors, Adrenergic, alpha

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