| Catecholamines in cerebrospinal fluid are increased by behavioral arousal and myocardial ischemia. | |
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MedLine Citation:
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PMID: 1636775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the central neural mechanisms involved in malignant ventricular arrhythmia, concentrations of norepinephrine in the cerebrospinal fluid were measured during behavioral stimulation and during coronary artery occlusion. Pigs were instrumented via thoracotomy with catheters to measure mean arterial pressure and plasma catecholamines and with silk snares around the left anterior descending coronary artery for occlusion after recovery from surgery. Cannulas were placed in the lateral ventricle of the brain to sample cerebrospinal fluid. Behavioral arousal was induced by lifting the pig in a canvas sling for 5 min. Mean arterial pressure, heart rate, and both plasma and cerebrospinal fluid norepinephrine concentrations increased significantly after lifting stimulation. In a separate experiment, 5 min after coronary artery occlusion, both plasma catecholamines and norepinephrine in cerebrospinal fluid were significantly elevated. Furthermore, pigs in which ventricular fibrillation occurred after occlusion had significantly higher concentrations of norepinephrine in cerebrospinal fluid before coronary artery occlusion. |
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Authors:
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D A Johnson; J M Pinto; D A Kirby; B Lown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 263 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-08-24 Completed Date: 1992-08-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H83-7 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arousal / physiology* Behavior, Animal / physiology* Coronary Disease / blood, cerebrospinal fluid*, complications Epinephrine / blood, cerebrospinal fluid* Female Male Norepinephrine / blood, cerebrospinal fluid* Physical Stimulation Specimen Handling Ventricular Fibrillation / etiology |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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