Document Detail

Catecholamines and haemodynamics in fixed essential hypertension.
MedLine Citation:
PMID:  540429     Owner:  NLM     Status:  MEDLINE    
1. Arterial plasma catecholamines and haemodynamic status were simultaneously studied in 27 patients with fixed essential hypertension (WHO I-II). 2. Total arterial plasma catecholamines were found to be directly related to mean arterial pressure and to calculated total peripheral resistance, and they were inversely related to stroke index. 3. The degree of total peripheral resistance reduction after alpha-receptor blockade (phentolamine 10 mg intravenously) and the degree of mean arterial pressure reduction after combined alpha- and beta- receptor blockade (labetalol 100 mg intravenously) were directly related to pretreatment plasma catecholamine concentrations. 4. These findings support the view that the sympathetic nervous system, as evaluated by plasma catecholamine concentration, may have an important role in maintaining hypertension in a subgroup of patients, contributing mainly to the degree of peripheral vasoconstriction.
E Agabiti-Rosei; C Alicandri; R Fariello; G Muiesan
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  57 Suppl 5     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-06-25     Completed Date:  1980-06-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  193s-196s     Citation Subset:  IM    
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MeSH Terms
Blood Pressure* / drug effects
Cardiac Output / drug effects
Epinephrine / blood*
Heart Rate / drug effects
Hypertension / physiopathology*
Labetalol / diagnostic use
Middle Aged
Norepinephrine / blood*
Phentolamine / diagnostic use
Vascular Resistance / drug effects
Reg. No./Substance:
36894-69-6/Labetalol; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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