Document Detail

Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora's box?
MedLine Citation:
PMID:  18079995     Owner:  NLM     Status:  MEDLINE    
It is well established that catecholamines (CAs), which regulate immune and inflammatory responses, derive from the adrenal medulla and from presynaptic neurons. Recent studies reveal that T cells also can synthesize and release catecholamines which then can regulate T cell function. We have shown recently that macrophages and neutrophils, when stimulated, can generate and release catecholamines de novo which, then, in an autocrine/paracrine manner, regulate mediator release from these phagocytes via engagement of adrenergic receptors. Moreover, regulation of catecholamine-generating enzymes as well as degrading enzymes clearly alter the inflammatory response of phagocytes, such as the release of proinflammatory mediators. Accordingly, it appears that phagocytic cells and lymphocytes may represent a major, newly recognized source of catecholamines that regulate inflammatory responses.
Michael A Flierl; Daniel Rittirsch; Markus Huber-Lang; J Vidya Sarma; Peter A Ward
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Molecular medicine (Cambridge, Mass.)     Volume:  14     ISSN:  1076-1551     ISO Abbreviation:  Mol. Med.     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-05-27     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9501023     Medline TA:  Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-204     Citation Subset:  IM    
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA.
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MeSH Terms
Catecholamines / chemistry,  metabolism*
Immune System / physiology
Inflammation / immunology*
Molecular Structure
Phagocytes / metabolism
T-Lymphocytes / metabolism
Grant Support
Reg. No./Substance:

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