| Catecholaminergic polymorphic ventricular tachycardia: electrocardiographic characteristics and optimal therapeutic strategies to prevent sudden death. | |
| | |
MedLine Citation:
|
PMID: 12482795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the clinical outcome, ECG characteristics, and optimal treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), a malignant and rare ventricular tachycardia. PATIENTS AND METHODS: Questionnaire responses and ECGs of 29 patients with CPVT were evaluated. Mean (SD) age of onset was 10.3 (6.1) years. RESULTS: The initial CPVT manifestations were syncope (79%), cardiac arrest (7%), and a family history (14%). ECGs showed sinus bradycardia and a normal QTc. Mean heart rate during CPVT was 192 (30) beats/min. Most cases were non-sustained (72%), but 21% were sustained and 7% were associated with ventricular fibrillation. The morphology of CPVT was polymorphic (62%), polymorphic and bidirectional (21%), bidirectional (10%), or polymorphic with ventricular fibrillation (7%). There was 100% inducement of CPVT by exercise, 75% by catecholamine infusion, and none by programmed stimulation. No late potential was recorded. Onset was in the right ventricular outflow tract in more than half the cases. During a follow up of 6.8 (4.9) years, sudden death occurred in 24% of the patients, 7% of whom had anoxic brain damage. Autosomal dominant inheritance was seen in 8% of the patients' families. beta Blockers completely controlled CPVT in only 31% of cases. Calcium antagonists partially suppressed CPVT in autosomal dominant cases. CONCLUSIONS: CPVT may arise in certain distinct areas but the prognosis is poor. The onset of CPVT may be an indication for an implanted cardioverter-defibrillator. |
| | |
Authors:
|
N Sumitomo; K Harada; M Nagashima; T Yasuda; Y Nakamura; Y Aragaki; A Saito; K Kurosaki; K Jouo; M Koujiro; S Konishi; S Matsuoka; T Oono; S Hayakawa; M Miura; H Ushinohama; T Shibata; I Niimura |
Related Documents
:
|
15364745 - Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocar... 19589795 - Electrophysiological findings in patients with isolated left ventricular non-compaction. 688755 - Pharmacokinetic and pharmacodynamic studies of procainamide given intermittently intrav... 9160225 - Effect of waveform tilt on defibrillation thresholds in humans. 17924235 - A longitudinal study of diffusion tensor mri in als. 20711095 - Central diabetes insipidus induced by tuberculosis in a rheumatoid arthritis patient. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 89 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2002-12-16 Completed Date: 2003-01-31 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 66-70 Citation Subset: AIM; IM |
Affiliation:
|
Department of Paediatrics, Nihon University School of Medicine, Itabashi, Tokyo, Japan. jt9n-smtm@asahi-net.or.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adrenergic beta-Antagonists / therapeutic use Adult Anti-Arrhythmia Agents / therapeutic use Catecholamines / genetics* Catheter Ablation / methods Child Child, Preschool Death, Sudden, Cardiac / prevention & control* Echocardiography Electrocardiography Female Heart Rate Humans Male Polymorphism, Genetic Survival Rate Tachycardia, Ventricular / mortality, physiopathology*, therapy* Treatment Outcome Verapamil / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Catecholamines; 52-53-9/Verapamil |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of glucose-insulin-potassium infusion on chronic ischaemic left ventricular dysfunction.
Next Document: Assessment of myocardial viability using coronary zero flow pressure after successful angioplasty in...