Document Detail

Catecholaminergic involvement in the biphasic effect of ADATN on temperature in mice.
MedLine Citation:
PMID:  7250189     Owner:  NLM     Status:  MEDLINE    
A prodrug of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADHTN), 2-amino-6,7-diacetoxy-1,2,3,4-tetrahydronaphthalene (ADATN), was tested for activation of central dopaminergic receptors as measured by colonic temperature in mice. Intraperitoneal injections of ADATN (200 and 800 mumol/kg) produced hypothermia; and intermediate dose (400 mumol/kg) caused hyperthermia followed by hypothermia. A similar biphasic effect occurred with the one dose of ADHTN (800 mumol/kg) tested. Pretreatments with catecholaminergic antagonists were used to characterize the biphasic effect of the intermediate dose of ADATN. The hyperthermic phase depended on the release of endogenous catecholamines which activated alpha- and beta-adrenergic receptors. The hypothermic phase was mediated by a direct activation of dopaminergic receptors. The results are discussed in terms of the pharmacodynamics of a prodrug, the actions of ADHTN, and the known effects of indirect- and direct-acting catecholaminergic agonists on temperature. The involvement of different catecholaminergic systems in the effects of ADATN may limit its usefulness as a dopaminergic prodrug.
D J Dooley; M J Namkung; A A Hungar; A Horita; D M Bowden
Related Documents :
6308149 - Brain receptor changes in parkinson's disease in relation to the disease process and tr...
2883609 - Denervation supersensitivity of striatal d2 dopamine receptors is restricted to the ven...
17224059 - Angiotensin type 1 receptor antagonist losartan, reduces mptp-induced degeneration of d...
18504119 - Pre- and post-synaptic dopamine imaging and its relation with frontostriatal cognitive ...
6972799 - Role of substantia nigra pars reticulata neurons in the expression of neuroleptic-induc...
2536879 - Chronic neuroleptic treatment in rats produces persisting changes in gabaa and dopamine...
10771169 - Nk-3 receptors are expressed on mouse striatal gamma-aminobutyric acid-ergic interneuro...
22272819 - A bret assay for monitoring insulin receptor interactions and ligand pharmacology.
6474189 - Differential development of two classes of acetylcholine receptors in xenopus muscle in...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  71     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  269-76     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Temperature / drug effects*
Catecholamines / physiology*,  secretion
Dose-Response Relationship, Drug
Naphthalenes / pharmacology*
Receptors, Adrenergic / drug effects
Receptors, Dopamine / drug effects
Tetrahydronaphthalenes / pharmacology*
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Naphthalenes; 0/Receptors, Adrenergic; 0/Receptors, Dopamine; 0/Tetrahydronaphthalenes; 53463-78-8/ADTN; 82205-64-9/2-amino-6,7-diacetoxy-1,2,3,4-tetrahydronaphthalene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of right stellate ganglion stimulation on regional myocardial blood flow and ischemic injury...
Next Document:  Pharmacological studies with several analogs of mazindol: correlation between effects on dopamine up...