Document Detail


Catecholaminergic involvement in the biphasic effect of ADATN on temperature in mice.
MedLine Citation:
PMID:  7250189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prodrug of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADHTN), 2-amino-6,7-diacetoxy-1,2,3,4-tetrahydronaphthalene (ADATN), was tested for activation of central dopaminergic receptors as measured by colonic temperature in mice. Intraperitoneal injections of ADATN (200 and 800 mumol/kg) produced hypothermia; and intermediate dose (400 mumol/kg) caused hyperthermia followed by hypothermia. A similar biphasic effect occurred with the one dose of ADHTN (800 mumol/kg) tested. Pretreatments with catecholaminergic antagonists were used to characterize the biphasic effect of the intermediate dose of ADATN. The hyperthermic phase depended on the release of endogenous catecholamines which activated alpha- and beta-adrenergic receptors. The hypothermic phase was mediated by a direct activation of dopaminergic receptors. The results are discussed in terms of the pharmacodynamics of a prodrug, the actions of ADHTN, and the known effects of indirect- and direct-acting catecholaminergic agonists on temperature. The involvement of different catecholaminergic systems in the effects of ADATN may limit its usefulness as a dopaminergic prodrug.
Authors:
D J Dooley; M J Namkung; A A Hungar; A Horita; D M Bowden
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  71     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  269-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature / drug effects*
Catecholamines / physiology*,  secretion
Dose-Response Relationship, Drug
Male
Mice
Naphthalenes / pharmacology*
Receptors, Adrenergic / drug effects
Receptors, Dopamine / drug effects
Tetrahydronaphthalenes / pharmacology*
Grant Support
ID/Acronym/Agency:
RR00166/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Naphthalenes; 0/Receptors, Adrenergic; 0/Receptors, Dopamine; 0/Tetrahydronaphthalenes; 53463-78-8/ADTN; 82205-64-9/2-amino-6,7-diacetoxy-1,2,3,4-tetrahydronaphthalene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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