Document Detail


Catecholamine and thyroid hormones in traumatic injury.
MedLine Citation:
PMID:  2302947     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During hyperthyroidism, hypothyroidism, and severe stress there is often an inverse relationship between plasma norepinephrine (NE) and thyroid hormones. We evaluated this relationship in patients who were severely burned, patients who had injury to both brain and body, patients with head injury, and patients receiving high dose barbiturates for head injury. Head-injured patients had a low thyroxine (T4), low triiodothyronine (T3), and high reverse T3. Phenytoin for control of seizures lowered T3 and T4 and increased thyroid-stimulating hormone. Burned patients had a strong negative correlation between NE and T3 (r = -.88, p less than .001). Patients with injury to both brain and body had a weak negative correlation between NE and T3 (r = -.5, p = .06). Patients with head injury showed no correlation between NE and T3. Severely injured patients had a close inverse relationship between elevated NE levels and depressed T3 levels. This relationship appears to depend on an intact CNS, as the relationship was disrupted by head injury and barbiturates.
Authors:
M G Ziegler; E C Morrissey; L F Marshall
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  18     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-03-27     Completed Date:  1990-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of California San Diego Medical Center 92103.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain Injuries / blood
Burns / blood
Catecholamines / blood*
Craniocerebral Trauma / blood,  drug therapy
Female
Humans
Male
Middle Aged
Norepinephrine / blood
Phenytoin / pharmacology,  therapeutic use
Thyroid Hormones / blood*
Triiodothyronine / blood
Wounds and Injuries / blood*
Grant Support
ID/Acronym/Agency:
HL 35924/HL/NHLBI NIH HHS; N01-NS-3-2339/NS/NINDS NIH HHS; RR MO1-00827/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Thyroid Hormones; 51-41-2/Norepinephrine; 57-41-0/Phenytoin; 6893-02-3/Triiodothyronine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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