Document Detail

Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.
MedLine Citation:
PMID:  25118721     Owner:  NLM     Status:  Publisher    
Objective:We performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with subsequent development of catecholamine-resistant hypotension following ligation.Study Design:A standardized treatment approach for hypotension was followed at each center. Infants were considered to have catecholamine-resistant hypotension if their dopamine infusion was >15 μg kg(-1)min(-1). Echocardiograms and cortisol measurements were obtained between 6 and 14 h after the ligation (prior to the presence of catecholamine-resistant hypotension).Result:Forty-five infants were enrolled, 10 received catecholamines (6 were catecholamine-responsive and 4 developed catecholamine-resistant hypotension). Catecholamine-resistant hypotension was not associated with decreased preload, shortening fraction or ventricular output. Infants with catecholamine-resistant hypotension had significantly lower levels of systemic vascular resistance and postoperative cortisol concentration.Conclusion:We speculate that low cortisol levels and impaired vascular tone may have a more important role than impaired cardiac performance in post-ligation catecholamine-resistant hypotension.Journal of Perinatology advance online publication, 14 August 2014; doi:10.1038/jp.2014.151.
S Noori; P McNamara; A Jain; P M Lavoie; A Wickremasinghe; T A Merritt; T Solomon; K Sekar; J T Attridge; J R Swanson; M Gillam-Krakauer; J Reese; B B Poindexter; M Brook; R J Auchus; R I Clyman; ;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-14
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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MeSH Terms
Ronald Clyman / ; Andrea Wickremasinghe / ; Michael Brook / ; Richard Auchus / ; Susan Matthews / ; Robert Chomic / ; Stephen C Brown / ; T Allen Merritt / ; Tabitha Solomon / ; Michael Kuhn / ; Patrick McNamara / ; Amish Jain / ; Afif El-Khuffash / ; Jenny Luc / ; Shahab Noori / ; Krishnamurthy Sekar / ; Michael McCoy / ; Karen Corff / ; Pascal Lavoie / ; Jennifer Claydon / ; Nadine Lusney / ; Kristi Finlay / ; Joshua T Attridge / ; Amy E Blackman / ; Jonathan R Swanson /

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