Document Detail

Catecholamine release: mechanism of mercury-induced vascular smooth muscle contraction.
MedLine Citation:
PMID:  238407     Owner:  NLM     Status:  MEDLINE    
The mechanism by which mercuric ion (HgCl2) induces contraction of vascular smooth muscle was defined in the kidney of anesthetized dogs and in rabbit aortic strips. In vivo, HgCl2 injected into the renal artery induced a dose-related reduction in renal blood flow (electromagnetic flowmeter) and glomerular filtration rate (creatinine clearance). An intra-arterial infusion of phenoxybenzamine (POB) significantly reduced the vascular response to HgCl2 (P less than 0.001). In vitro, alpha-adrenergic blockade with phentolamine and POB prevented mercury-induced contraction, whereas agents that block serotonin, histamine, acetylcholine, and angiotensin did not do so. Norepinephrine receptor "protection" from phenoxybenzamine blockade sustained the response to HgCl2. Reserpine pretreatment produced a parallel reduction in the response of the aorta to tyramine and mercury. The results are consistent with an indirect action of mercuric ion via release of endogenous catecholamines.
H S Solomon; N K Hollenberg
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  229     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-10-11     Completed Date:  1975-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8-12     Citation Subset:  IM; S    
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Angiotensin II / pharmacology
Aorta / drug effects
Glomerular Filtration Rate
Kidney / blood supply
Mercury / antagonists & inhibitors,  pharmacology*
Muscle Contraction / drug effects*
Muscle, Smooth / metabolism,  physiology*
Norepinephrine / antagonists & inhibitors,  metabolism*
Phenoxybenzamine / pharmacology
Phentolamine / pharmacology
Receptors, Adrenergic
Reserpine / pharmacology
Tyramine / antagonists & inhibitors
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Chlorides; 0/Receptors, Adrenergic; 11128-99-7/Angiotensin II; 50-55-5/Reserpine; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-67-2/Tyramine; 59-96-1/Phenoxybenzamine; 7439-97-6/Mercury

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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