Document Detail

Catecholamine release in human heart by bupropion.
MedLine Citation:
PMID:  12706471     Owner:  NLM     Status:  MEDLINE    
Although there are some data on the cardiovascular profile of bupropion, a non-nicotine-based pharmacotherapy for smoking cessation, detailed studies of its specifically cardiac effects are lacking. In particular, the direct action of this agent on human myocardial contractility is not known. Therefore, we investigated the effects of bupropion on human cardiac tissue in vitro. Our results suggest that bupropion exerts indirect sympathomimetic activity producing positive inotropic effects in human myocardium most probably by catecholamine release.
Bodo Cremers; Kathrin I Schmidt; Christoph Maack; Hans Joachim Schäfers; Michael Böhm
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  467     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-22     Completed Date:  2003-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätskliniken des Saarlandes, 66421 Homburg, Germany.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Bupropion / pharmacology*
Catecholamines / metabolism*
Dose-Response Relationship, Drug
Drug Interactions
Heart Atria / drug effects
Myocardial Contraction / drug effects*
Myocardium / metabolism*
Propanolamines / pharmacology
Stimulation, Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Catecholamines; 0/Propanolamines; 34841-39-9/Bupropion; 70369-47-0/bucindolol

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