| Catecholamine levels in hypoxia-lnduced acute mountain sickness. | |
| | |
MedLine Citation:
|
PMID: 19378908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Enhanced sympathoadrenal activity has been implicated in the pathogenesis of acute mountain sickness (AMS). This study was designed to examine the time course of circulating catecholamines in individuals with and without AMS. METHODS: Subjects were low-altitude residents (10 men, 8 women) who had not been exposed to altitude within the previous 2 mo. They breathed 12% O2 (hypoxia equivalent to 4600 m altitude) for 8 h while seated at rest. AMS was evaluated using Lake Louise scores (LLS) at 0, 1, 3, 5, and 7 h of exposure using a threshold of 3 to define AMS. Blood samples were collected to measure arterial blood gases and oxygen saturation as well as arterial and venous epinephrine (A-EPI and V-EPI) and norepinephrine (A-NE and V-NE). RESULTS: Eight subjects (44%) developed AMS at some time during the experiment. Blood gases showed no significant difference between subjects with or without symptoms (AMS+ and AMS-, respectively). However, AMS+ subjects showed significantly greater concentrations of A-EPI over the 8 h without any between-group difference in V-EPI. Levels of A-NE were significantly higher at baseline and during the first hour of hypoxia in subjects who later developed AMS. V-NE increased significantly over time among all participants with no difference between groups. CONCLUSIONS: These findings suggest a possible physiological marker for individuals who may be relatively susceptible to AMS and provide additional insight into the sympathoadrenal response to acute hypoxia. |
| | |
Authors:
|
Gary H Kamimori; Edward J Ryan; Ronald Otterstetter; Jacob E Barkley; Ellen L Glickman; Harry Q Davis |
Related Documents
:
|
20619878 - Blood total mercury and fish consumption in the korean general population in knhanes ii... 8760208 - Respiration and medullary blood flow during sinusoidal hypoxia in the peripherally chem... 3080728 - Alterations in cerebral blood flow and oxygen consumption during prolonged hypocarbia. 3790138 - Effects of haematocrit value and glucagon on the metabolism of perfused rat liver. 3289468 - Toxicological quandary of the use of bis (2-diethylhexyl) phthalate (dehp) as a plastic... 2772978 - Regional cerebral blood flow measurement with intravenous [15o]water bolus and [18f]flu... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Aviation, space, and environmental medicine Volume: 80 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-04-21 Completed Date: 2009-06-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
|
Languages: eng Pagination: 376-80 Citation Subset: IM; S |
Affiliation:
|
Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. gary.kamimori@us.army.mil |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Altitude Sickness / blood* Anoxia / blood*, physiopathology Biological Markers / blood Blood Gas Analysis Epinephrine / blood* Female Humans Male Norepinephrine / blood* Severity of Illness Index Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pulmonary barotrauma in divers during emergency free ascent training: review of 124 cases.
Next Document: Crash rates of scheduled commuter and air carrier flights before and after a regulatory change.