Document Detail

Catecholamine-induced pulmonary edema and pleural effusion in rats--alpha- and beta-adrenergic effects.
MedLine Citation:
PMID:  12706063     Owner:  NLM     Status:  MEDLINE    
We investigated the contribution of alpha- and beta-adrenergic pathways to catecholamine-induced pulmonary edema and the role of pleural effusion in preventing alveolar edema. Female Sprague-Dawley rats received continuous intravenous infusion of norepinephrine and of separate alpha- or beta-adrenergic stimulation over 6-24 h. We performed heart catheterization in vivo and excised post mortem lung tissue for histological analysis. Interleukin (IL)-6 and total protein concentrations were determined in serum, pleural fluid (PF) and bronchoalveolar lavage fluid. alpha-Adrenergic treatment increased right ventricular systolic pressure (RVSP) and total peripheral resistance (TPR) and caused severe alveolar edema associated with IL-6 activation in serum and diffuse pulmonary inflammation. PF amounts were moderate (0.9+/-0.2 ml). beta-Adrenergic stimulation also increased RVSP but decreased TPR. Interstitial but not alveolar edema and focal inflammation without IL-6 activation developed. Large PF amounts (6.2+/-1.5 ml) occurred which were considered to prevent alveolar edema. We conclude that both alpha- and beta-adrenergic stimulation contribute to pulmonary fluid shifts in rats, but alpha-adrenergic pathways cause more acute and more severe lung injury than beta-adrenergic mechanisms.
Beate Rassler; Christian Reissig; Wilfried Briest; Andrea Tannapfel; Heinz Gerd Zimmer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  135     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-22     Completed Date:  2003-07-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  25-37     Citation Subset:  IM    
Carl-Ludwig-Institute of Physiology, Liebigstr. 27, D-04103, Leipzig, Germany.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-Agonists / pharmacology*
Adrenergic beta-Antagonists / pharmacology
Enzyme-Linked Immunosorbent Assay
Hemodynamics / drug effects*
Interleukin-6 / analysis
Lung / pathology
Norepinephrine / pharmacology
Pleural Effusion / chemically induced*,  immunology
Proteins / analysis
Pulmonary Edema / chemically induced*,  immunology
Rats, Sprague-Dawley
Time Factors
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Interleukin-6; 0/Proteins; 51-41-2/Norepinephrine

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