Document Detail


Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.).
MedLine Citation:
PMID:  19903379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Myocardial fibrosis and oxidative stress accompany a number of cardiac disorders such as hypertrophic cardiomyopathy, hypertensive heart disease and cardiac failure. Stem bark of Terminalia arjuna has been advocated for cardiac ailments. The present study evaluated the effects of T. arjuna bark extract on myocardial fibrosis and oxidative stress induced by chronic beta-adrenoceptor stimulation.
METHODS: Aqueous extract of T. arjuna bark was evaluated at 63, 125 and 250 mg/kg given orally for antifibrotic and antioxidant effects in rats given the selective beta-adrenoceptor agonist isoprenaline (5 mg/kg s.c.) for 28 days. Captopril (50 mg/kg per day, given orally), an inhibitor of angiotensin-converting enzyme used as a standard cardioprotective drug, was used as a positive control.
KEY FINDINGS: Isoprenaline caused fibrosis, increased oxidative stress and cardiac hypertrophy (increased heart weight : body weight ratio and cardiomyocyte diameter). The T. arjuna bark extract and captopril significantly prevented the isoprenaline-induced increase in oxidative stress and decline in endogenous antioxidant level. Both also prevented fibrosis but not the increase in heart weight : body weight ratio.
CONCLUSIONS: T. arjuna protects against myocardial changes induced by chronic beta-adrenoceptor stimulation.
Authors:
Santosh Kumar; Rajesh Enjamoori; Amardeep Jaiswal; Ruma Ray; Sandeep Seth; Subir Kumar Maulik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  61     ISSN:  2042-7158     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-11     Completed Date:  2010-03-16     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1529-36     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists
Animals
Antioxidants / pharmacology*
Captopril / pharmacology
Cardiomegaly / drug therapy
Fibrosis / chemically induced,  prevention & control
Heart / drug effects
Isoproterenol / pharmacology
Male
Myocardium / pathology*
Organ Size
Oxidative Stress / drug effects*
Peptidyl-Dipeptidase A
Phytotherapy*
Plant Bark
Plant Extracts / pharmacology*
Plant Stems
Rats
Rats, Wistar
Terminalia*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Antioxidants; 0/Plant Extracts; 62571-86-2/Captopril; 7683-59-2/Isoproterenol; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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