| Catecholamine effects on cardiac remodelling, oxidative stress and fibrosis in experimental heart failure. | |
| | |
MedLine Citation:
|
PMID: 12189044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of the study was to assess the relationships between oxidative stress, cardiac remodelling and fibrosis on an experimental model of heart failure with adrenergic stimulation. Large myocardial infarction (approximately 50% of the left ventricle myocardium) was obtained by ligation of the left coronary artery of normotensive male Wistar rats. Sham animals were submitted to left thoracotomy without coronary ligation. In order to perform cardiac stimulation by catecholamines, mini-osmotic pumps were implanted in animals 10 weeks after surgery to deliver noradrenalin for a 2-week period. At the end of this period, the following investigations were performed: haemodynamics, morphometry, fibrosis quantification, plasma and tissue catecholamine assay and oxidative stress status. Coronary ligation induced dilatation of left ventricle with compensatory hypertrophy of the right ventricle and of the remaining left ventricle myocardium. This remodelling process was associated in non-infarcted myocardium with increased collagen infiltration and increased oxidative stress. Ten weeks after surgery, the chronic administration of noradrenalin for 2 weeks did not increase oxidative stress. Noradrenalin, however, induced inotropic stimulation and myocardial hypertrophy, but to a lesser extent in infarcted rats compared to sham rats. Our results suggest that noradrenalin infusion to levels in excess of those seen post-infarction is associated with fibrosis and oxidative stress. Moreover, noradrenalin in infarcted animals caused additional fibrosis without further increasing oxidative stress. The mechanism of catecholamine-induced fibrosis may thus involve different processes such as ischaemia, increased mechanical stress, cytokines and neurohormones. |
| | |
Authors:
|
Dominique Bonnefont-Rousselot; Allal Mahmoudi; Nathalie Mougenot; Odile Varoquaux; Gilles Le Nahour; Pierre Fouret; Philippe Lechat |
Related Documents
:
|
11191364 - Effects of adaptation to intermittent high altitude hypoxia on ischemic ventricular arr... 12921804 - Pulmonary endothelium as a site of synthesis and storage of interleukin-6 in experiment... 16651724 - Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. 19098114 - N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induc... 15801274 - Effectiveness of distal protection with the guardwire plus during primary angioplasty f... 1588674 - The cardiovascular system after scorpion envenomation. a review. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Redox report : communications in free radical research Volume: 7 ISSN: 1351-0002 ISO Abbreviation: Redox Rep. Publication Date: 2002 |
Date Detail:
|
Created Date: 2002-08-21 Completed Date: 2003-02-12 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9511366 Medline TA: Redox Rep Country: England |
Other Details:
|
Languages: eng Pagination: 145-51 Citation Subset: IM |
Affiliation:
|
Laboratoire de Biochimie B, Coeur et Vaisseaux, Groupe Hospitalier Pitié-Salpêtrière (AP-HP), 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France. dominique.rousselot@psl.ap-hop-paris.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease Models, Animal Echocardiography Fibrosis Heart / drug effects, physiopathology* Heart Failure / physiopathology* Hemodynamics / physiology* Male Myocardial Infarction / physiopathology* Myocardium / metabolism, pathology Norepinephrine / pharmacology* Oxidative Stress / drug effects* Rats Rats, Wistar Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Thiobarbituric Acid Reactive Substances; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage a...
Next Document: Hydroxyl radical scavenging action of capsaicin.