| Catecholamine content changes in brain regions of spontaneously hypertensive rats under immobilization stress. | |
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MedLine Citation:
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PMID: 2918315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared the effect of immobilization stress on noradrenaline (NA) and 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) content in two brain regions--diencephalon and pons-medulla oblongata--in young and adult spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). In SHR, NA content decreased with time after the onset of the stress, whereas levels of its metabolite MHPG increased. In WKY, NA and MHPG showed no change. The MHPG/NA ratio in both regions increased relative to the duration of the stress in SHR, whereas it remained almost constant in WKY. The rate of increase in the ratio was much higher in the diencephalon of adult (12-week-old) than of young (4-week-old) SHR. In SHR, NA turnover in the brain is readily affected by environmental stress, and these changes in the noradrenergic system may induce or sustain hypertension. |
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Authors:
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M Nomura; K Okamura |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 52 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-03-24 Completed Date: 1989-03-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 933-7 Citation Subset: IM; S |
Affiliation:
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Department of Physiology, School of Medicine, Fujita-Gakuen Health University, Aichi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism Animals Brain / metabolism* Diencephalon / metabolism Glycols / metabolism* Hypertension / metabolism* Kinetics Medulla Oblongata / metabolism Methoxyhydroxyphenylglycol / metabolism* Norepinephrine / metabolism* Pons / metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Restraint, Physical Stress, Physiological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glycols; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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