| Catecholamine-associated refractory hypertension following acute intracranial hemorrhage: control with propranolol. | |
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MedLine Citation:
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PMID: 7224599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seven patients (4 with subarachnoid hemorrhage, 2 with intracerebral hemorrhage, and 1 with massive cerebral infarction) had acute arterial hypertension refractory to control by several antihypertensive drugs (hydralazine, sodium nitroprusside, alpha-methyldopa, and trimethaphan camsylate) used singly or in combination. In each case, catecholamine excretion--measured by urinary norepinephrine plus epinephrine--was markedly elevated, averaging 218 microgram/day. Patients without the acute refractory hypertension had normal or only slightly elevated urinary catecholamine levels (mean, 72 microgram/day). The beta-adrenergic blocking agent propranolol, in doses between 20 and 40 mg every 6 hours, successfully controlled blood pressure, while other agents failed. The intense sympathetic nervous system discharge resulting in acute refractory hypertension may be due to injury to the diencephalon or brainstem (or both) or to diffuse brain dysfunction from increased intracranial pressure or intracranial blood. |
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Authors:
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J H Feibel; C A Baldwin; R J Joynt |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of neurology Volume: 9 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1981 Apr |
Date Detail:
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Created Date: 1981-06-25 Completed Date: 1981-06-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 340-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / therapeutic use* Cerebral Hemorrhage / complications*, urine Epinephrine / urine* Female Humans Hypertension / drug therapy*, urine Intracranial Aneurysm / complications Male Middle Aged Norepinephrine / urine* Propranolol / therapeutic use Subarachnoid Hemorrhage / complications |
| Grant Support | |
ID/Acronym/Agency:
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NS14178-03/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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