Document Detail


(+)-Catechin is more bioavailable than (-)-catechin: relevance to the bioavailability of catechin from cocoa.
MedLine Citation:
PMID:  17015247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Catechin is a flavonoid present in fruits, wine and cocoa products. Most foods contain the (+)-enantiomer of catechin but chocolate mainly contains ( - )-catechin, in addition to its major flavanol, ( - )-epicatechin. Previous studies have shown poor bioavailability of catechin when consumed in chocolate. We compared the absorption of ( - ) and (+)-catechin after in situ perfusion of 10, 30 or 50 micromol/l of each catechin enantiomer in the jejunum and ileum in the rat. We also assayed 23 samples of chocolate for (+) and ( - )-catechin. Samples were analyzed using HPLC with a Cyclobond I-2000 RSP chiral column. At all concentrations studied, the intestinal absorption of ( - )-catechin was lower than the intestinal absorption of (+)-catechin (p < 0.01). Plasma concentrations of ( - )-catechin were significantly reduced compared to (+)-catechin (p < 0.05). The mean concentration of ( - )-catechin in chocolate was 218 +/- 126 mg/kg compared to 25 +/- 15 mg/kg (+)-catechin. Our findings provide an explanation for the poor bioavailability of catechin when consumed in chocolate or other cocoa containing products.
Authors:
Jennifer L Donovan; Vanessa Crespy; Manuel Oliveira; Karen A Cooper; Bryan B Gibson; Gary Williamson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Free radical research     Volume:  40     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-03     Completed Date:  2006-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1029-34     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability
Cacao / chemistry*
Catechin / analysis*,  blood,  pharmacokinetics*
Intestinal Absorption
Intestine, Small / physiology
Male
Perfusion
Rats
Rats, Wistar
Stereoisomerism
Chemical
Reg. No./Substance:
154-23-4/Catechin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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