| Catch-up and targeted growth following variable duration protein restriction: Effects on bone and body mass. | |
| | |
MedLine Citation:
|
PMID: 21290419 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Protein malnutrition leads to growth retardation that can be reversed through catch-up growth, once normative nutrition is restored. Because growth is a dynamic process, catch-up capacity is likely influenced by the maturity of the animal and/or the duration of the insult, in addition to the type of insult experienced. We compared length of malnutrition, sexual dimorphism, body mass, and skeletal growth. Eighty Rattus norvegicus were divided into 10 treatment groups (five diets; male and female) and followed for more than 1 year. At weaning, animals were placed on either a control or low-protein isocaloric diet. Three experimental groups were switched to the control diet at 40, 60, or 90 days. Beginning with 21 days of age, animals were weighed daily and radiographed throughout the study. To determine the presence of catch-up growth, growth rates (GRs) were calculated (linear regression) for 20-day time spans before and after diet changes and compared among treatment groups. Targeted growth was measured as final size or as the coefficient of variation with age. These results show that 1) protein-restricted animals experience catch-up growth with dietary rehabilitation; 2) for females, catch-up GRs are proportional to GRs in control animals at the same age as the timing of dietary rehabilitation but not for males; and 3) targeted growth was observed in some, but not all, aspects of anatomy. The length of the tibia and humerus was indistinguishable from controls, regardless of length of malnutrition or gender, whereas the ulna and male body mass exceeded control sizes. Although most measures decreased in variation with ontogeny, the tibia failed to do so. These results support a complex biological regulation of catch-up and targeted growth. The implications for selection are that flexible and responsive developmental trajectories may have an advantage over those programed into a single size. J. Morphol., 2011. © 2011 Wiley-Liss, Inc. |
| | |
Authors:
|
Donna Carlson Jones; Marica Bernstein; Rebecca Z German |
Related Documents
:
|
1662069 - The effects of dietary levels of inorganic phosphorus, calcium and cholecalciferol on t... 6264809 - Intestinal absorption of calcium: role of dietary phosphate and vitamin d. 12370839 - A calcium-deficient diet caused decreased bone mineral density and secondary elevation ... 3575329 - Effects of ovariectomy on duodenal calcium transport in the rat: altered ability to ada... 18073279 - Learned appetites for calcium, phosphorus, and sodium in sheep. 9239459 - Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice. 2304709 - Influence of dietary zinc and iron on zinc retention in pregnant rhesus monkeys and the... 9730039 - Measurement error from assessing use of vitamin supplements at one point in time. 8429289 - The malmö biological bank. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-2 |
Journal Detail:
|
Title: Journal of morphology Volume: - ISSN: 1097-4687 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0406125 Medline TA: J Morphol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
Department of Physical Medicine and Rehabilitation, The Johns Hopkins University, Baltimore, Maryland 21231. donna.jones1@cchmc.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Scanning electron microscopy of the placental interface in the viviparous lizard Sceloporus jarrovi ...
Next Document: Angioarchitecture of the bovine spermatic cord.