Document Detail

Catatonic syndrome in a general psychiatric inpatient population: frequency, clinical presentation, and response to lorazepam.
MedLine Citation:
PMID:  2211547     Owner:  NLM     Status:  MEDLINE    
In a prospective open trial conducted on a general psychiatric ward, the authors diagnosed catatonic syndrome 15 times in 12 patients over a 1-year period. These 12 patients represented 9% of all admissions. The following signs were present in two thirds or more of the episodes studied: immobility (100%), staring (92%), mutism (85%), withdrawal/refusal to eat (78%), posturing/grimacing (73%), and rigidity (66%). Other signs of catatonia were seen less frequently. Lorazepam 1 to 2 mg was administered in every case, and patients were evaluated at hourly intervals. Of the 15 episodes, 12 responded completely and dramatically to lorazepam treatment within 2 hours, 1 responded partially, and 2 had no response. Adverse effects were infrequent. A CNS abnormality or dysfunction was evident in 8 of the 12 responders, suggesting that a beneficial response to lorazepam is not limited to patients with pure psychogenic catatonia. The prompt recognition and treatment of catatonia may reduce morbidity in and length of stay for hospitalized psychiatric patients.
P I Rosebush; A M Hildebrand; B G Furlong; M F Mazurek
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  51     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-11-01     Completed Date:  1990-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Aged, 80 and over
Catatonia / complications,  diagnosis,  drug therapy*
Length of Stay
Lorazepam / therapeutic use*
Mental Disorders / complications,  psychology*
Middle Aged
Prospective Studies
Reg. No./Substance:

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