Document Detail


Catatonia and neuroleptic malignant syndrome: two disorders on a same spectrum? Four case reports.
MedLine Citation:
PMID:  23274293     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT: We present the history of four bipolar patients who developed neuroleptic malignant syndrome (NMS) after antipsychotic treatment, focusing on the relationship between NMS and catatonia. In all cases, the administration of antipsychotics has been suspended as soon as fever and autonomic disturbances occurred. A supportive therapy was initiated to stabilize general conditions, then every patient started electroconvulsive therapy (ECT) in combination with benzodiazepines (BDZ). The risk of complications was reduced by the quick adoption of supportive care, whereas the combination of ECT and BDZ was effective in resolving the clinical picture. These cases may provide further support to the hypothesis that catatonia and NMS are disorders pertaining to the same spectrum of illness because the onset or exacerbation of catatonic symptoms coincided with the administration of antipsychotics. Our experience confirms the efficacy and safety of ECT in combination with BDZ as treatment of NMS and residual catatonia.
Authors:
Federica Luchini; Lorenzo Lattanzi; Natalia Bartolommei; Luca Cosentino; Antonella Litta; Christine Kansky; Mauro Mauri; Giovanni Battista Cassano; Andrea Fagiolini; Francesco Casamassima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  201     ISSN:  1539-736X     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  36-42     Citation Subset:  AIM; IM    
Affiliation:
*Department of Psychiatry, Neurobiology, Pharmacology and Bio-technologies, University of Pisa, Pisa, Italy; †Thomas Jefferson Medical School, Philadelphia, PA; and ‡Department of Neuroscience, Section of Psychiatry, University of Siena, Siena, Italy.
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