Document Detail


Catastrophic antiphospholipid syndrome.
MedLine Citation:
PMID:  16880085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Catastrophic APS is a potentially life-threatening condition with a high mortality, which requires high clinical awareness. New mechanisms for its production can only be explored if samples are obtained, stored, and dis-patched to investigation sites in Europe (Barcelona), the United States (Atlanta), and Japan (Sapporo). Details will be posted and made available on the International Registry Web Site in 2006. It is essential that the condition be diagnosed early and treated aggressively. The combination of high doses of iv heparin, iv steroids plus repeated doses of iv gammaglobulins or plasma exchange is the treatment of choice in patients with this severe condition. Additionally, preventive measures in patients with APS may be effective if the development of the catastrophic APS is to be avoided.
Authors:
Ricard Cervera; Ronald A Asherson; Josep Font
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Rheumatic diseases clinics of North America     Volume:  32     ISSN:  0889-857X     ISO Abbreviation:  Rheum. Dis. Clin. North Am.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-01     Completed Date:  2006-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708093     Medline TA:  Rheum Dis Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-90     Citation Subset:  IM    
Affiliation:
Department of Autoimmune Diseases, Hospital Clínic, Villarroel 170, 08036-Barcelona, Catalonia, Spain. rcervera@clinic.ub.es
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / therapeutic use
Antiphospholipid Syndrome / complications*,  diagnosis,  physiopathology
Catastrophic Illness
Combined Modality Therapy
Early Diagnosis
Glucocorticoids / therapeutic use
Heparin / therapeutic use
Humans
Immunoglobulins, Intravenous
Multiple Organ Failure / diagnosis,  etiology*,  therapy
Plasma Exchange
Thrombosis
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Glucocorticoids; 0/Immunoglobulins, Intravenous; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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