Document Detail

Cataracts in Atopic Dermatitis: A Case Presentation and Review of the Literature.
MedLine Citation:
PMID:  21242345     Owner:  NLM     Status:  Publisher    
BACKGROUND: Atopic dermatitis (AD) is a common skin disorder of increasing prevalence. Many ophthalmologic conditions are associated with AD, including cataract formation. Posterior and anterior subcapsular cataracts have been described in AD. Topical and systemic corticosteroids have been implicated in the development of cataracts. The precise pathogenic mechanisms and risk factors for development of atopic cataract are not clear. Observation  We report a case of cataract development in a child with severe AD and performed an extensive review of the dermatologic and ophthalmologic literature pertaining to AD and cataract formation. The incidence, demographics, pathogenesis, and characteristics of atopic cataracts are evaluated. CONCLUSIONS: Atopic dermatitis alone is a risk factor to develop both posterior and anterior subcapsular cataracts. There is a slightly increased probability of posterior subcapsular cataracts. However, anterior subcapsular cataracts are more specific to AD. A positive correlation was found between atopic cataract development and a decreased inducibility of superoxide dismutase. This suggests that atopic cataract development is correlated with oxidative damage of the lens and related to chronic inflammation.
Brooke Bair; John Dodd; Karen Heidelberg; Kent Krach
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-17
Journal Detail:
Title:  Archives of dermatology     Volume:  -     ISSN:  1538-3652     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Ann Arbor, Michigan (Drs Bair, Dodd, Heidelberg, and Krach); and Departments of Dermatology (Drs Bair, Heidelberg, and Krach) and Ophthalmology (Dr Dodd), St John's Providence Health System, Oakland Hospital, Madison Heights, Michigan.
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