Document Detail


Cataract extraction and cognitive function in older women.
MedLine Citation:
PMID:  12843777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxidative damage is critical in the etiology of cataract. Therefore, associations between cataract and other health endpoints may suggest the shared etiologic role of oxidative stress. METHODS: To assess any role of oxidative stress in cognitive function and early cognitive decline, we investigated the relation between cognition and cataract extraction in 16,197 community-dwelling women age 70-79 years from the Nurses' Health Study. Six cognitive tests were administered by telephone from 1995 to 2000; second interviews are ongoing and have been completed for 12,995 women. In total, 3,597 women reported cataract extraction prior to their baseline cognitive assessment. We used logistic regression to calculate multivariate-adjusted relative risks of a low score and of substantial decline, comparing those with and without cataract extraction. RESULTS: Using a global score that combines the results of the cognitive tests, there was no relation between cataract and either low score (RR = 0.99; 95% CI = 0.87-1.13) or substantial decline from baseline to second interview (RR = 1.08; CI = 0.93-1.25). CONCLUSION: Cataract extraction does not appear to be related to cognitive function in these women.
Authors:
Francine Grodstein; Jennifer Chen; Susan E Hankinson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  14     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-10-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  493-7     Citation Subset:  IM    
Affiliation:
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fran.grodstein@channing.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / psychology*
Cataract / physiopathology*
Cataract Extraction*
Cognition Disorders / etiology*
Cohort Studies
Female
Humans
Oxidative Stress*
Regression Analysis
Risk Assessment
Grant Support
ID/Acronym/Agency:
AG13483/AG/NIA NIH HHS; AG15424/AG/NIA NIH HHS; CA87969/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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