Document Detail

Catamnestic investigations in children with congenital hydrocephalus.
MedLine Citation:
PMID:  2375184     Owner:  NLM     Status:  MEDLINE    
Catamnestic investigations on the course of pregnancy, family history and genetics were carried out in 141 children suffering from congenital hydrocephalus. The results were compared with those obtained from a group of non-malformed controls investigated by the same criteria. There was a considerably higher incidence of pregnancy disturbances (i.e. diseases, drugs, haemorrhage etc.) in mothers who later gave birth to a child with congenital hydrocephalus, than mothers of the control group (congenital hydrocephalus: 61.3% vs. controls: 30.1%). This high incidence of pregnancy disturbances could be particularly referred to a sevenfold increased rate of diseases and a fourfold increased rate of drug intake during the first trimester. There was also a higher rate of malformed relatives in children with congenital hydrocephalus (16.7%) than in controls (6.4%); not only were malformations of the central nervous system found to be increased but also malformations of other organ systems in relatives. This is interpreted as a hint not only at genetic influences but also at a generally higher incidence of malformations in a relatively small group of persons. Calculated figures of recurrence risk were in accordance with empirical data used in genetic counselling.
T A Angerpointner; L Pockrandt; K Schroer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zeitschrift für Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft für Kinderchirurgie = Surgery in infancy and childhood     Volume:  45     ISSN:  0174-3082     ISO Abbreviation:  Z Kinderchir     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-08-27     Completed Date:  1990-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8103794     Medline TA:  Z Kinderchir     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Paediatric Surgical Clinic, Dr. von Haunersches Kinderspital of the University of Munich, F.R.G.
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MeSH Terms
Abnormalities, Multiple
Birth Weight
Child, Preschool
Diseases in Twins
Drug Therapy / adverse effects
Follow-Up Studies
Gestational Age
Hydrocephalus / etiology*,  genetics,  surgery
Infant, Newborn
Maternal Age
Paternal Age
Pregnancy Complications / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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