Document Detail


Catalytically increased prebiotic peptide formation: ditryptophan, dilysine, and diserine.
MedLine Citation:
PMID:  16231205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
"Mutual" amino acid catalysis of glycine on the formation of ditryptophan, dilysine, and diserine in the prebiotically relevant Salt-Induced Peptide Formation (SIPF) Reaction was investigated varying the starting concentration and chirality of the educt amino acid, and analyzing the increase of yield resulting from this catalytic effect. Our results show the possibility of an amplified diverse pool of peptides being available for chemical evolution of larger peptides and proteins using also these more complicated amino acids for the evolution of more complex functions in future biochemical cycles and thus for the emergence of life. Catalytic effects are especially high in the case of serine, the most basic amino acid of the three, but are also significant for the other two examples investigated in the present work. Besides that, especially for serine, but also in the case of tryptophan, differences in catalytic yield increase according to the chiral form of the amino acid used could be observed.
Authors:
Kristof Plankensteiner; Hannes Reiner; Bernd M Rode
Related Documents :
2327965 - High-efficiency transpeptidation catalysed by clostripain and electrostatic effects in ...
597595 - The origin of the protein synthesis mechanism.
7216615 - 3-nitro-2-pyridinesulfenyl (npys) group. a novel selective protecting group which can b...
2696585 - Chemistry and biology of nitrosated peptides.
7081435 - Renal tubular transport of folic acid and methotrexate in the monkey.
14565545 - Study of stability of methotrexate in acidic solution spectrofluorimetric determination...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life     Volume:  35     ISSN:  0169-6149     ISO Abbreviation:  Orig Life Evol Biosph     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2006-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610391     Medline TA:  Orig Life Evol Biosph     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  411-9     Citation Subset:  IM; S    
Affiliation:
Division of Theoretical Chemistry, Institute of General, Inorganic, and Theoretical Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Biogenesis*
Catalysis
Chromatography, High Pressure Liquid
Dipeptides / chemical synthesis*,  chemistry
Evolution, Chemical*
Serine / chemistry
Tryptophan / chemistry
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Dipeptides; 13184-13-9/lysyllysine; 56-45-1/Serine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nitrogen fixation by corona discharge on the early precambrian Earth.
Next Document:  Aqueous synthesis of peptide thioesters from amino acids and a thiol using 1,1'-carbonyldiimidazole.