| Catalytic metallodrugs targeting HCV IRES RNA. | |
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MedLine Citation:
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PMID: 22343977 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay. |
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Authors:
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Seth Bradford; J A Cowan |
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Publication Detail:
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Type: Journal Article Date: 2012-02-16 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 48 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 3118-20 Citation Subset: IM |
Affiliation:
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Department of Chemistry, The Ohio State University, 100 W, 18th Ave, Columbus, OH 43210, USA. cowan@chemistry.ohio-state.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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