Document Detail


Catalytic metallodrugs targeting HCV IRES RNA.
MedLine Citation:
PMID:  22343977     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay.
Authors:
Seth Bradford; J A Cowan
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Publication Detail:
Type:  Journal Article     Date:  2012-02-16
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  48     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  3118-20     Citation Subset:  IM    
Affiliation:
Department of Chemistry, The Ohio State University, 100 W, 18th Ave, Columbus, OH 43210, USA. cowan@chemistry.ohio-state.edu.
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