Document Detail


CATALYTIC DYNAMIC RESOLUTION APPLIED TO THE SYNTHESIS OF 2,6-DISUBSTITUTED PIPERIDINES: PREPARATION OF (+)-LUPETIDINE AND (-)-EPIDIHYDROPINIDINE.
MedLine Citation:
PMID:  22408286     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The diastereoselective synthesis of trans-2,6-disubstituted piperidines has been rendered enantioselective by incorporating a catalytic dynamic resolution into the first alkylation step. The method has been applied to the synthesis of (-)-epidihydropinidine and (+)-trans-lupetidine.
Authors:
Timothy K Beng; Robert E Gawley
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Heterocycles     Volume:  84     ISSN:  0385-5414     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513602     Medline TA:  Heterocycles     Country:  -    
Other Details:
Languages:  ENG     Pagination:  697-718     Citation Subset:  -    
Affiliation:
Department of Chemistry and Biochemistry, University of Arkansas, 119 Chemistry, Fayetteville, Arkansas, USA 72701.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P30 RR031154-02//NCRR NIH HHS

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