Document Detail


Catalytic therapy of cancer with ascorbate and extracts of medicinal herbs.
MedLine Citation:
PMID:  18955293     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Catalytic therapy (CT) is a cancer treatment modality based on the generation of reactive oxygen species (ROS) using a combination of substrate molecules and a catalyst. The most frequently used substrate/catalyst pair is ascorbate/Co phthalocyanine (PcCo). In the present work, herb extracts containing pigments have been studied as a catalyst in place of PcCo. Extracts from herbs are expected to have efficiency comparable with that of phthalocyanines but as natural products, to exhibit fewer side effects. The present studies demonstrate that a combined use of ascorbate and herbal extracts results in ROS production and a significant decrease in the number of cancer cells after a single in vitro treatment. Treatment with ascorbate in conjunction with extracts prepared from several medicinal herbs stimulated apoptosis and disrupted the cell cycle. The number of cells accumulating in the sub-G0/G1 stage of the cell cycle was increased 2- to 7-fold, and cells in G(2)/M increased 1.5- to 20-fold, indicating that the treatment protocol was highly effective in suppressing DNA synthesis and potentially reflecting DNA damage in the tumor cells. In addition, 20-40% of the cells underwent apoptosis within 24 h of completing treatment. Our results suggest that herbal extracts can function as CT catalysts in the treatment of cancer.
Authors:
Nadejda Rozanova Torshina; Jin Z Zhang; Diane E Heck
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Publication Detail:
Type:  Journal Article     Date:  2007-12-26
Journal Detail:
Title:  Evidence-based complementary and alternative medicine : eCAM     Volume:  7     ISSN:  1741-4288     ISO Abbreviation:  Evid Based Complement Alternat Med     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-07-14     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  101215021     Medline TA:  Evid Based Complement Alternat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  -    
Affiliation:
Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064 and Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61605, USA.
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