Document Detail


Catalytic enantioselective cyclization and C3-fluorination of polyenes.
MedLine Citation:
PMID:  23282101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
(Xylyl-phanephos)Pt(2+) in combination with XeF(2) mediates the consecutive diastereoselective cation-olefin cyclization/fluorination of polyene substrates. Isolated yields were typically in the 60-69% range while enantioselectivities reached as high as 87%. The data are consistent with a stereoretentive fluorination of a P(2)Pt-alkyl cation intermediate.
Authors:
Nikki A Cochrane; Ha Nguyen; Michel R Gagne
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  135     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-06-19     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  628-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alkenes / chemistry*
Catalysis
Cyclization
Halogenation
Molecular Structure
Polyenes / chemistry*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
GM-60578/GM/NIGMS NIH HHS; R01 GM060578/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Alkenes; 0/Polyenes
Comments/Corrections

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