| Catalyst Evolution by Serendipitous Hydrolysis of Phosphoramidite Ligand: Rh(I)-Catalyzed Enantioselective Hydrogenation of -Substituted Ethenylphosphonic Acids. | |
| | |
MedLine Citation:
|
PMID: 22783876 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A type of chiral Rh(I) catalysts containing monodentate phosphorous acid diesters tautomerized from its secondary phosphine oxide was discovered by serendipitous hydrolysis of phosphoramidite ligands. The evolved catalyst demonstrated unprecedented enantioselectivities (98->99% ee's) and high catalytic activities (as low as 0.01 mol % catalyst loading) in asymmetric hydrogenation of a wide variety of -aryl or alkyl substituted ethenylphosphonic acids, one type of challenging olefinic substrates, providing a facile approach to the corresponding enantiopure phosphonic acids with significant biological importance. |
| | |
Authors:
|
Kaiwu Dong; Zheng Wang; Kuiling Ding |
Related Documents
:
|
455246 - Electrophoresis of tissue glycosaminoglycans as an aid in the diagnosis of mesotheliomas. 10097326 - Acid-fast bacterial infection and its control in guppies (lebistes reticulatus) reared ... 20124066 - Carbodiimide-derivatized hyaluronic acid surface modification of lyophilized flexor ten... 22405756 - Utilization of crude karanj (pongamia pinnata) oil as a potential feedstock for the syn... 19161276 - Synthesis of conformationally preorganized and cell-permeable guanidine-based gamma-pep... 9672716 - Amino acid metabolism and the energetics of growth. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-11 |
Journal Detail:
|
Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: L-cysteine supplementation as an adjuvant therapy for type-2 diabetes.
Next Document: Highly conserved low-copy nuclear genes as effective markers for phylogenetic analyses in angiosperm...