Document Detail

Catalyst Evolution by Serendipitous Hydrolysis of Phosphoramidite Ligand: Rh(I)-Catalyzed Enantioselective Hydrogenation of -Substituted Ethenylphosphonic Acids.
MedLine Citation:
PMID:  22783876     Owner:  NLM     Status:  Publisher    
A type of chiral Rh(I) catalysts containing monodentate phosphorous acid diesters tautomerized from its secondary phosphine oxide was discovered by serendipitous hydrolysis of phosphoramidite ligands. The evolved catalyst demonstrated unprecedented enantioselectivities (98->99% ee's) and high catalytic activities (as low as 0.01 mol % catalyst loading) in asymmetric hydrogenation of a wide variety of -aryl or alkyl substituted ethenylphosphonic acids, one type of challenging olefinic substrates, providing a facile approach to the corresponding enantiopure phosphonic acids with significant biological importance.
Kaiwu Dong; Zheng Wang; Kuiling Ding
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-11
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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