| Catalpol increases brain angiogenesis and up-regulates VEGF and EPO in the rat after permanent middle cerebral artery occlusion. | |
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MedLine Citation:
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PMID: 20827397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the role and mechanism of catalpol in brain angiogenesis in a rat model of stroke, the effect of catalpol (5 mg/kg; i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. Repeated treatments with Catalpol reduced neurological deficits and significantly improved angiogenesis, while significantly increasing brain levels of EPO and VEGF without worsening BBB edema. These results suggested that catalpol might contribute to infarcted-brain angiogenesis and ameliorate the edema of brain capillary endothelial cells (BCECs) by upregulating VEGF and EPO coordinately. |
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Authors:
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Hui-Feng Zhu; Dong Wan; Yong Luo; Jia-Li Zhou; Li Chen; Xiao-Yu Xu |
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Publication Detail:
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Type: Journal Article Date: 2010-08-20 |
Journal Detail:
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Title: International journal of biological sciences Volume: 6 ISSN: 1449-2288 ISO Abbreviation: Int. J. Biol. Sci. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235568 Medline TA: Int J Biol Sci Country: Australia |
Other Details:
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Languages: eng Pagination: 443-53 Citation Subset: IM |
Affiliation:
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School of Pharmaceutical Sciences & School of Chinese Medicine, Southwest University, Chongqing 400715, China. zhfbsci@yahoo.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Endothelial Cells / drug effects Erythropoietin / genetics, metabolism* Heart / drug effects, physiopathology* Immunohistochemistry Infarction, Middle Cerebral Artery / metabolism, physiopathology* Iridoid Glucosides / pharmacology* Male Myocardium / metabolism*, pathology Neovascularization, Physiologic / drug effects* Psychomotor Performance / drug effects Rats Rats, Sprague-Dawley Up-Regulation Vascular Endothelial Growth Factor A / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Iridoid Glucosides; 0/Vascular Endothelial Growth Factor A; 11096-26-7/Erythropoietin; 2415-24-9/catalpol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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