Document Detail

Catalase activity in Candida albicans exposed to antineoplastic drugs.
MedLine Citation:
PMID:  16476788     Owner:  NLM     Status:  MEDLINE    
An increased catalase activity in Candida spp. has been suggested as a mechanism that reduces amphotericin B activity. Furthermore, resistance to antifungal agents like amphotericin B has been reported in some cancer patients undergoing chemotherapy treatment. In this study we analysed the influence of chemotherapy agents on catalase activity in Candida albicans, the major species involved in yeast infections. Eight strains of C. albicans isolated from HIV-positive patients were exposed to cyclophosphamide, cytarabine, dacarbazine and methotrexate antineoplastic drugs at the concentrations used during therapy. Catalase activity was measured and compared to the control group. Very significant differences (P < 0.01) were found when C. albicans was exposed to methotrexate (2 microg ml(-1) = 4 microM). For cyclophosphamide (50 microg ml(-1)), cytarabine (1 microg ml(-1)) and dacarbazine (8 microg ml(-1)), no differences were found (P > 0.05) between the control and drug-exposed groups. Although more extensive studies are necessary, these data do suggest that the antineoplastic drug methotrexate contributes to the resistance to antifungal drug therapy by varying catalase activity.
Carlos E B Linares; Deizi Griebeler; Denise Cargnelutti; Sydney H Alves; Vera M Morsch; Maria R C Schetinger
Related Documents :
17394608 - Anidulafungin--state of affairs from a clinical perspective.
18625768 - In vivo pharmacodynamic target investigation for micafungin against candida albicans an...
10091478 - Current topics in diagnosis and treatment of tinea unguium in japan.
17305778 - Amphotericin b deoxycholate (d-amb) use in cases with febrile neutropenia and fungal in...
11286798 - Dinitroaniline herbicides against protozoan parasites: the case of trypanosoma cruzi.
6268388 - Diagnosis and treatment of five parasites. enterobius vermicularis, giardia lamblia, tr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical microbiology     Volume:  55     ISSN:  0022-2615     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-14     Completed Date:  2006-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900. Santa Maria, RS, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antimetabolites, Antineoplastic / pharmacology*
Candida albicans / drug effects*,  enzymology*
Catalase / metabolism*
Methotrexate / pharmacology
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 59-05-2/Methotrexate; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Natural resistance, iron and infection: a challenge for clinical medicine.
Next Document:  Transcriptional profiling of host responses in mouse lungs following aerosol infection with type A F...