| Catabolite repression directly affects transcription of the qa-y gene of Neurospora crassa. | |
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MedLine Citation:
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PMID: 19236936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The quinic acid (qa) gene cluster of Neurospora crassa is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source, e.g. glucose. RNA blot analysis revealed that transcription of the qa-y gene, which encodes a quinic acid permease, was strongly repressed in the presence of glucose even in the absence of the qa-1S repressor protein, while transcription of the remaining qa cluster genes is repressed to a much lesser degree. DNA sequencing of the region upstream of the qa-y gene revealed a high degree of sequence conservation between N. crassa and the homothallic species Neurospora africana and Neurospora terricola. This may suggest the presence of conserved sequences that mediate catabolite repression in all three species. |
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Authors:
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Diana R Arnett; Heather E Lorimer; David K Asch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-02-21 |
Journal Detail:
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Title: Fungal genetics and biology : FG & B Volume: 46 ISSN: 1096-0937 ISO Abbreviation: Fungal Genet. Biol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-15 Completed Date: 2009-05-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607601 Medline TA: Fungal Genet Biol Country: United States |
Other Details:
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Languages: eng Pagination: 377-80 Citation Subset: IM |
Affiliation:
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Kent State University, OH 44242, United States. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/DQ015972; DQ015973 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Northern Conserved Sequence DNA, Fungal / chemistry, genetics Down-Regulation Gene Expression Regulation, Fungal* Gene Order Glucose / metabolism Models, Biological Molecular Sequence Data Neurospora crassa / physiology* Promoter Regions, Genetic RNA, Fungal / biosynthesis RNA, Messenger / biosynthesis Sequence Analysis, DNA Transcription, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Fungal; 0/RNA, Fungal; 0/RNA, Messenger; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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