Document Detail

Catabolite repression directly affects transcription of the qa-y gene of Neurospora crassa.
MedLine Citation:
PMID:  19236936     Owner:  NLM     Status:  MEDLINE    
The quinic acid (qa) gene cluster of Neurospora crassa is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source, e.g. glucose. RNA blot analysis revealed that transcription of the qa-y gene, which encodes a quinic acid permease, was strongly repressed in the presence of glucose even in the absence of the qa-1S repressor protein, while transcription of the remaining qa cluster genes is repressed to a much lesser degree. DNA sequencing of the region upstream of the qa-y gene revealed a high degree of sequence conservation between N. crassa and the homothallic species Neurospora africana and Neurospora terricola. This may suggest the presence of conserved sequences that mediate catabolite repression in all three species.
Diana R Arnett; Heather E Lorimer; David K Asch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-21
Journal Detail:
Title:  Fungal genetics and biology : FG & B     Volume:  46     ISSN:  1096-0937     ISO Abbreviation:  Fungal Genet. Biol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-15     Completed Date:  2009-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607601     Medline TA:  Fungal Genet Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-80     Citation Subset:  IM    
Kent State University, OH 44242, United States.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/DQ015972;  DQ015973
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MeSH Terms
Blotting, Northern
Conserved Sequence
DNA, Fungal / chemistry,  genetics
Gene Expression Regulation, Fungal*
Gene Order
Glucose / metabolism
Models, Biological
Molecular Sequence Data
Neurospora crassa / physiology*
Promoter Regions, Genetic
RNA, Fungal / biosynthesis
RNA, Messenger / biosynthesis
Sequence Analysis, DNA
Transcription, Genetic*
Reg. No./Substance:
0/DNA, Fungal; 0/RNA, Fungal; 0/RNA, Messenger; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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